The darkDNA group encompasses all aspects of modern genetics, bioinformatics, structural and systems biology approaches. The aim is to combine multi-dimensional genomic information, to investigate complex molecular systems, heredity, population genetics and even complex diseases. In fact, the darkDNA group coalesces various fields of state of the art research in genetics into a multidiscipline approach adjusted to meet the needs of the post-Genomic era.
CHECK OUT SOME OF OUR ONLINE VIDEOS including PRESS RELEASES, INTERVIEWS & lots of SCIENCE
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... I’ll finish by saying that the idea we will try to check is that exosomes are something like viruses, circulating from one cell to another. We could call them endocrine retroviruses, if you like. This is a new piece of work that shows how cells can communicate, coordinate, and interact, influencing each other and dynamically designing and modifying their epigenetic profiles...
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... I’ll finish by saying that the idea we will try to check is that exosomes are something like viruses, circulating from one cell to another. We could call them endocrine retroviruses, if you like. This is a new piece of work that shows how cells can communicate, coordinate, and interact, influencing each other and dynamically designing and modifying their epigenetic profiles...
Read MoreThese are some of the most significant work we have published within darkDNA. The full list of 282 articles is HERE
Guerra J , Valadao AL, Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N. Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. Science Advances. 2020, (3) 10; e1700495, DOI: 10.1126/sciadv.1700495 LINK
Vila IK, Chamma H, Steer A, Saccas M, Taffoni C, Turtoi E, Reinert LS, Hussain S, Marines J, Jin L, Bonnefont X, Hubert M, Schwartz O, Paludan SR, Van Simaeys G, Doumont G, Sobhian B, Vlachakis D, Turtoi A, Laguette N. Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses Cell Metabolism 2022 Jan 4;34(1):125-139.e8. *Feautured Cover in CELL METABOLISM vol.34(1):2022 doi: 10.1016/j.cmet.2021.12.007 LINK
Antoniou N, Vlachakis D, Memou A, Leandrou E, Valkimadi PE, Melachroinou K, Re DB, Przedborski S, Dauer WT, Stefanis L, Rideout HJ.
A motif within the armadillo repeat of Parkinson’s-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway.
Scientific Reports (NPG). 2018 (8):3455 LINK
Tsiliki G, Vlachakis D, Kossida S. On integrating multi-platform microarray data. Philos Trans A Math Phys Eng Sci
Royal Society
2014
20130136 LINK
Naseem M, Othman EM, Fathy M, Iqbal J, Howari FM, AlRemeithi FA, Kodandaraman G, Stopper H, Bencurova E, Vlachakis D, Dandekar T. Integrated structural and functional analysis of the protective effects of kinetin against oxidative stress in mammalian cellular systems
Nature Sci Rep 2020 Aug 7;10(1):13330 LINK
DNA-PK controls cyclic dinucleotide-associated type I Interferon responses. Clara Taffoni, Isabelle K. Vila, Jane Jardine, Moritz Schussler, Joe McKellar, Morgane Chemarin, Joanna Re, Yasmine Messaout-Nacer, Insaf El Mansouri, George P Chrousos, Nicolas Bidère, Karim Majzoub, Dimitrios Vlachakis, Nadine Laguette. bioRxiv 2024.09.17.613246; doi: https://doi.org/10.1101/2024.09.17.613246 LINK
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